developed Ab3-8, which does not directly inhibit ASCT2 but inhibits glutamine uptake by inducing the internalization of ASCT2 (Hara et al., 2020)
According to KEGG pathway analysis, the cAMP signaling pathway (hsa04024), MAPK signaling pathway (hsa04010), Neuroactive ligand-receptor interaction (hsa04080), T-cell receptor signaling pathway (hsa04660), Relaxin signaling pathway (hsa04926), Calcium signaling pathway (hsa04020), Ras signaling pathway (hsa04014), PI3K-Akt signaling pathway (hsa04151), Neurotrophin signaling pathway (hsa04722) are highly enriched (Figure 11C)
Pre-mixed blends are best reserved for the maintenance phase once both compounds are at stable target doses
At these times you may need to supplement with glutamine
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doi: 10.1074/jbc.RA118.004479 226 TeeleD