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Kamintsky, L

, MoralesRuiz, M

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Following studies by our center showed that a low C/D ratio increases the risk of developing acute CNI-induced nephrotoxicity and was associated with a faster decline of eGFR, higher rejection rates and, most importantly, a reduced patient as well as overall graft survival within 5 years after RTx (87, 144)

Moreover, PAT induce DNA damage and cell cycle arrest along with intrinsic pathway mediated apoptosis which may have dermal toxicological implications [172]