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Ireland and France levy the highest excise duties on cigarettes in the EU, at 8.42 ($9.60) and 6.61 ($7.53) per 20-cigarette pack, respectively

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Chronic depression requiring pharmacological treatment was diagnosed in 3 patients (1 adult female and 2 adolescents), one of the latter showed a self-injurious behavior and attempted suicide (Additional Table 1)

All experiments were performed in accordance with guidelines/regulations which were reviewed and approved by the joint Clinical Research Ethics Board of the University of British Columbia and BC Cancer (#H12-00727)

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