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Mutations in ELAC2 associated with hypertrophic cardiomyopathy impair mitochondrial tRNA 3-end processing
The table also details novel mechanisms, including the roles of Alas2 overexpression [94], SPRY4-ERK1/2 phosphorylation [107], and the interplay between p66Shc-Sirt1 [54], the ADMA-DDAH1 axis [56], and Hypoxia-Inducible Factor 1-alpha (HIF-1) signaling [105]
Several endogenous metabolites, including ubiquinol, vitamin E, and vitamin K hydroquinone, function as radical-trapping antioxidants that terminate lipid peroxyl radicals and suppress ferroptotic membrane damage 84-87
Apoptosis in the human allografted kidney
(00:04:14) Amy Epstein: That's right
Nevertheless, PS translocation to the outer leaflet of the phospholipid bilayer, a hallmark of eryptosis, can frequently occur without caspase-3 recruitment, primarily in response to Ca 2+ overload [84]
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