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Research has shown that vitamin D deficiency or insufficiency contributes to the seasonal nature of cold and flu outbreaks less sunlight means less vitamin D production in the skin, which is linked to lower immunity and the possibility of more illness

Burnett B, Li F, Pittman RN

Rats'appetites increase and their weight increases when the proglucagon gene, which encodes GLP- 1, is less expressed in the nucleus tractus solitarius [110, 111]

doi: 10.4274/tjod.32656 102 XuZTongWYangZZhangHChenX

[23] Additionally, a 2018 observational study suggested an elevated risk of developing inflammatory bowel disease, specifically ulcerative colitis, which peaked after three to four years of use and decreased after more than four years