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Possible long-term risks of vitamin B12 Most side effects of high doses of B12 are rare and temporary

Split dosing: Some practitioners split the daily dose into 250 mcg AM and 250 mcg pre-sleep on the rationale that two smaller pulses maintain steadier receptor exposure

Over-the-counter pain relievers can help temporarily, but they dont fix the underlying issue and may hinder long-term tissue repair

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In theory, once youve healed, you can stop and maintain the improvement

This unique property means both local and systemic administration can support healing, though local injection near the injury typically produces faster results