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And finally, potential synergy: therapies targeting hypoxia and HIF-1 may have the potential to create synergies with existing drugs compared to existing treatments, thereby enhancing the therapeutic effect (233)

doi: 10.20944/preprints201909.0043.v2 387 SweetmanEKleffmannTEdgarCde LangeMVallingsRTateW

Preclinical research in animal models shows that BPC-157 protects against NSAID-induced gastric ulcers, chemically induced intestinal lesions, and stress-related gut injuries, improving mucosal integrity and reducing symptoms such as abdominal pain, bloating, and diarrhea

ARC Is Regulated by MAPK and PI3K and Confers Drug Resistance and Survival Advantage to AML in vitro and in vivo

Kim DH et al (2011) Foxo6 integrates insulin signaling with gluconeogenesis in the liver