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Authors contributions Conceptualization: ROM, REW

GHK-Cu has the broadest base, with several decades of dermal, scalp and cosmetic-research publications, and a reasonable foundation in connective-tissue biology

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SIRT1, a nicotinamide adenine dinucleotide (NAD)-dependent histone deacetylase, is able to regulate inflammation, oxidative stress, mitochondrial function, immune response, cell differentiation, proliferation, and metabolism, and its dysfunction may participate in the development of autoimmune diseases (231)

Vukojevic et al., 2018) have been ascribed to BPC 157 therapy

Oshima, T., Miwa, H