This observation could possibly be explained by the accumulation of AGEs disrupting the regular force-transferring mechanisms of collagen fibrils
Skin aging is an inevitable biological phenomenon induced by internal and external factors
Also, ghrelin-deficient mice (ghrl/) display normal levels of hypothalamic orexigenic and anorexigenic neuropeptides, normal spontaneous food intake patterns, and growth rates, and a normal hyperphagic response to fasting
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Zhang Y, Fu Y, Jiang T, Liu B, Sun H, Zhang Y, et al
[ [PMID: 16756467] J