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When a disc bulges or herniates, it can place pressure on nearby nerves

3gss: AJ Oakley, J Rossjohn, M Lo Bello, AM Caccuri, G Federici & MW Parker (1997) The three-dimensional structure of the human Pi class glutathione transferase P1-1 in complex with the inhibitor ethacrynic acid and its glutathione conjugate

Topical copper peptides may help this look when the main driver is dermal thinning, but they work slowly and need steady use over months, not days

AST serves as a simple, quick, and low-cost screening method, while it may lack the sensitivity to detect transient or subtle autonomic abnormalities

Shaheen, MD, MPH, FACG, University of North Carolina, Chapel Hill, NC Updated June 2016

Neurosci Lett (2006) 396(1):6772