As one expert told NutraIngredients in December 2025: Its really a choose-your-own-adventure
Samra B, Kantarjian H, Sasaki K, Short N, Khouri R, Khoury J, Champlin R, Kebriaei P, Cortes JE, Jorgensen J, Wang SA, Garcia-Manero G, Kadia T, Borthakur G , Verstovsek S, Daver N, Montalban-Bravo G, Jain N, Konopleva M, Yilmaz M, Naqvi K, O'Brien S, Ravandi F, Jabbour E
While antiangiogenic therapies hold promise, their use must be carefully tailored to specific pathological contexts to avoid disrupting compensatory mechanisms that support neuronal health
In addition, in vitro assays in mouse macrophages revealed a significant increase in succinic acid expression upon glycolytic activation
(80) in the first phase of an international trial (see Table 2 )
Neither compound, in any formulation, can be legally dispensed as a pharmacy medicine as of this writing