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The utilisation of inhibitors of glutamine metabolism has been demonstrated to promote ROS formation and desensitization in PC cells, consequently resulting in altered cytokine-cytokine receptor interaction pathways, including those involving CCL5, CCR4, LTA, CXCR4, IL-6R and IL-7R, which in turn promote iron death [53]

Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide

2009;1(5):5ra11

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Tailor et al

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