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Elevated Cortisol and Prolactin Levels: May result in stress-related symptoms, decreased libido, and gynecomastia in men

[1] The affected genes cluster into several functional categories: Tissue repair and remodeling

This doesn't mean they're dangerous, but it means the full risk profile isn't established with the certainty that approved drugs provide

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L-citrulline , another amino acid, is converted to L-arginine in the kidneys and may actually raise plasma arginine levels more effectively than arginine supplementation itself, as it bypasses first-pass hepatic metabolism

The link between periodontal disease and rheumatoid arthritis: an updated review