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In practical terms, the difference is small enough that standard dosing protocols do not adjust for it

While various bio-delivery systems offer potential avenues for enhancing the bioavailability and biological efficacy of dietary polyphenols, it is imperative to address the bio-toxicity and biocompatibility concerns associated with these systems as exogenous antigens

Nat Rev Mol Cell Biol (2016) 17:61125

Glutathione peroxidase (GPx)-deficient mice spontaneously develop colitis 4

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Moreover, treatment with GP in mice with DSS-induced colitis resulted in the suppression of pro-inflammatory cytokines TNF-, IL-6, IL-1, IL-17A, and IFN-, modulation of intestinal barrier-related factors occludin-1 and ZO-1, enhancement of intestinal flora diversity, and an increase in Lactobacillus population [231]