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439 In addition, NR supplementation can also increase NAD + levels in the brain and reduce the levels of inflammatory cytokines in the cerebrospinal fluid, and NR can be used as a potential neuroprotective agent for PD (NCT03816020, NCT05344404)

Therefore, the problem that the agents successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events (60), may be at least partly solved with the more suited cuprizone model that reflects a toxic experimental model (12)

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but such effects are beyond the scope of this project and the numerical schemes that have been implemented

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Per- and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model