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h , Effects of PAPOLA overexpression on the proliferation of HL-60 cells and U-937 cells ( n = 3 technical replicates per group)

This is the earliest and most immediately perceptible effect

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GSH/GSSG-Glo allows for rapid, direct measurement of total and oxidized glutathione in cell-culture wells using low cell density.

However, a 2003 systematic review highlighted differences in methodologies between early and later studies that make it difficult to compare results (104)

Prevention by thiols suggests the inactivation by ebselen of a critical thiol essential for the catalytic activity of nitric oxide synthase