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Typical protocols involve daily doses of 200500 micrograms administered over 812 week cycles

Gruener, S., et al

B12 deficiency can also lead to the destruction of immature red blood cells in the bone marrow, which can cause jaundice (yellowing of the skin and whites of the eyes)

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showed that unfolding of cellular retinoic acid-binding protein I (CRABP I) is characterized by the formation of transiently populated intermediate states (Eyles et al., 1999)