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The study by Oehler and colleagues in 2002 (34) examined pathologic changes of the synovial membrane in patients with early-stage OA and identified four histological patterns of OA-associated synoviopathy: (i) synovial lining hyperplasia, (ii) sublining and capsular fibrosis, (iii) macromolecular cartilage and bone debris (detritus-rich), and (iv) inflammatory manifestations and stromal vascularization ( Figure 2 ) (29, 3538)

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Some medications prescribed for PCOS, like metformin, can even drain your body of B vitamins, making Vitamin B12 an essential supplement with a wide range of benefits for anyone with PCOS

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