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Lecithin for dementia and cognitive impairment

N,Nbis-(2-mercaptoethyl) isophthalamide (NBMI), a lipophilic thiol-based chelator with selective affinity for ferrous iron, has demonstrated superior brain chelation efficacy in a mouse model of brain iron overload, making it a promising candidate for IN formulations if its solubility limitations can be addressed ( The translation from animal studies to human therapy may face some hurdles, as rodents have a significantly larger olfactory epithelial surface area relative to their nasal cavities compared to humans

Neuroscience 189:370376

Mol Plant 2:344356 Queval G, Jaillard D, Zechmann B, Noctor G (2011) Increased intracellular H 2 O 2 availability preferentially drives glutathione accumulation in chloroplasts and vacuoles