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In the SIMGI model (an in vitro simulator of human digestion), a single dose of 0.166 g of PLAa widely used biodegradable plastic was followed by 72-h colonic fermentation

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Again, the loss of correlations in the pathway metabolite may be lost in patients due to illness-related, and also perhaps treatment influences, on 5-HIAA, since the TRP5-HIAA correlation is appears weakened in patients (Yao et al., 2010a)