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[DOI] [PMC free article] [PubMed] [Google Scholar] 47.High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis

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In cellular models using mouse brain endothelial cells as well as in vivo studies, it was shown that OC administration increased the brain efflux index of I-A40 in C57BL/6 wild-type mice from 62.0 3.0% to 79.9 1.6% (80, 81)

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10.3390/molecules24081583 [DOI] [PMC free article] [PubMed] [Google Scholar] Singh R., Panghal A., Jadhav K., Thakur A., Verma R

In clinical trials, IL-17 inhibitors (e.g., secukinumab and ixekizumab) and IL-23 inhibitors (e.g., guselkumab and tildrakizumab) have been associated with high rates of complete or near-complete cutaneous clearance