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doi: 10.1038/s41586-020-2732-8 25 ZouYLiHGrahamETDeikAAEatonJKWangWet al

doi: 10.1016/j.biopha.2021.111557

doi: 10.3390/cancers12020490 140 BerteroTOldhamWMGrassetEMBourgetIBoulterEPisanoSet al

doi: 10.1021/acs.jafc.6b04815 72

Under stimulation by lipopolysaccharide (LPS) and interferon- (IFN-), macrophages adopt the M1 phenotype ( 3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment ( 3.1 Oncogenic functions of tumor-associated macrophages Tumor-associated macrophages (TAMs) represent macrophages recruited and reprogrammed by the tumor microenvironment (TME), exhibiting distinct functional differences from conventional immune macrophages

Synergistic approaches have further improved curcumins efficacy