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discovered that insomnia is associated with significant changes in the structure and function of gut microbiota, showing reduced diversity (both -diversity and -diversity) and altered microbial interactions in individuals with insomnia compared to healthy controls [213]

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Persistent oxidative stress and induction of nuclear-factor-erythroid 2related-factor 2 (NRF2) antioxidant response in KO livers EtOH feeding decreased GSH levels specifically in the mitochondrial pool of livers of WT mice (Fig

Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)