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The overstimulation of neurons activates microglia, the resident immune cells of the brain, which release proinflammatory cytokines, such as TNF- and IL-1, as well as ROS (McConnell et al., 2015) (Figure 1)

The cells were incubated with varying concentrations of PDA and PDA@Pt for 24 h

doi: 10.1002/rmb2.12353 2 AgarwalASenguptaP

IV induction followed by SQ maintenance JAK inhibitors: Upadacitinib (Rinvoq) oral small molecule

Eur J Med Chem 232:114175 Anderson R, Feldman C (2023) The global burden of community-acquired pneumonia in adults, encompassing invasive pneumococcal disease and the prevalence of its associated cardiovascular events, with a focus on pneumolysin and macrolide antibiotics in pathogenesis and therapy