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In another in vitro and in vivo study, Nrf2/HO-1 was also demonstrated to play an important inhibitory role in the pro-fibrotic pathway activated by TGF-1, which was verified by oligo-fucoidan in NRK-52E cells and kidney tissues of C57BL/6 mice [151]

The film coating efficiently reduces ROS by activating the antioxidant enzymes SOD and G-POX and significantly induces NO production while reducing the l-Pro content and GR activity, whereas the CAT activity remains high when the film with SiNPs is applied