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The increase in UA following uricase knockout resulted in attenuation of behavioural and neurochemical pathology, while animals overexpressing this gene showed an enhancement of these measures

Through its interaction with NOTCH1, CHAC1/BOTCH inhibits NOTCH1 activity and thereby prevents neuronal stem cell self-renewal (Itoh et al., 2013

Glutathione, known as the body's master antioxidant, is vital for immune function and cellular integrity, impacting telomerase activity

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