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Finally, selective regulation within the sirtuin family is essential, as overactivation of SIRT1 could disrupt the functional balance of related sirtuins, necessitating careful control of activation intensity and tissue- or subcellular-specific delivery

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While excess inflammation is not ubiquitous in BD, it does present an opportunity to objectively segregate a large subset of patients who may respond better to targeted therapies

Glutathione also plays a key role in supporting liver function and may help prevent or manage nonalcoholic fatty liver disease by protecting the liver from oxidative stress and fat build-up

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