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GLS, one of the key enzymes in this pathway, is upregulated in various tumors and is thus considered a potential therapeutic target for cancer

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doi: 10.3389/fimmu.2021.652771 Summary Keywords trained immunity, inflammatory diseases, immune system, innate immune memory, epigenetic reprogramming, inflammation Citation Xu W, Guo Z, Xu T, Chen J, Chen L and Xu W (2025) Reversing inflammatory diseases via trained immunity: mechanisms, challenges, and prospects

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People with mutations in the enzymes that form glutathione are more susceptible to oxidative stress

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