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Protein Assay CBB Solution (5 ) (Nacalai Tesque, Kyoto, Japan) was diluted fivefold with ion-exchanged water and dispensed in 1.5 mL portions into 2 mL tubes

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were downregulated

medication mix and pricing are confirmed during the medical evaluation

However, an increase in mutation frequency above a critical threshold (usually 60%80%) leads to pathogenicity and mitochondrial disease manifestations (18, 19)

The clear separation between treatment and placebo groups (5272 vs 9.6 hairs) leaves little room for doubt about efficacy