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Growing research points to gut microbiome dysregulation and impaired gut barrier integrity as contributors to the chronic inflammation seen in PMOS

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A recent in vitro study showed that PINK1-dependent phosphorylation of Ser111 of Rab8A antagonistically regulates the phosphorylation of Thr72 of Rab8A by LRRK2 (Vieweg et al., 2020), suggesting that there might be even closer crosstalk between the two master kinase

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Sources: Pickart L, et al