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Digestive enzymes break down protein-based compounds before absorption

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They are included to illustrate general laboratory relevance and do not imply suitability for any personal, clinical, athletic, cosmetic, or veterinary purpose

Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T: Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study

or is there a safe area closer to the ankle to administer?

Before considering it, it's important to know who might benefit and who should be cautious