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Niosomes functionalized with a synthetic carbohydrate-binding agent for mannose-targeted doxorubicin delivery

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Briefly, cells pretreated with 4 mM glutamine (Gln) and 0 mM Gln, respectively, were cross-linked with formaldehyde at 37 C for 10 min, followed by the addition of glycine solution to quench the cross-linking reaction

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The ability to shuttle between the +1, +2, and +3 oxidation states is responsible for the versatile chemistry of vitamin B 12 , allowing it to serve as a donor of deoxyadenosyl radical (radical alkyl source) and as a methyl cation equivalent (electrophilic alkyl source)

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