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Most ZnTs are located within organellar membranes, serving various functions, such as filling vesicular zinc stores, supplying organelles with zinc, and loading exocytotic vesicles with zinc for essential biological processes

Co-crystal structures of GSTO1 with our inhibitors demonstrate covalent binding to the active site cysteine

Herpesvirus infection may be associated with an increased production of reactive oxygen species, molecular oxidative damage and changes in both non-enzymatic and enzymatic antioxidant defences 11,12,13,14,15

Iron-induced oxidative stress and ferroptosis in granulosa cells impair steroidogenesis, reduce mitochondrial function, and disrupt antioxidant defenses, leading to impaired folliculogenesis and oocyte maturation

Biomedicines 9:117