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References Akhtar TA, Orsomando G, Mehrshahi P, Lara-Nez A, Bennett MJ, Gregory JF III, Hanson AD

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Glutathione peroxidase (GPx) and superoxide dismutase (SOD) in oropharyngeal cancer associated with EBV and HPV coinfection

doi: 10.1155/2018/9547613 6

While necessary, this phase transforms toxins into "reactive intermediate metabolites" that are frequently more toxic and volatile than the original substance, generating massive amounts of free radicals