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Shriver SP, Bourdeau HA, Gubish CT, Tirpak DL, Davis AL, Luketich JD, Siegfried JM

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There is one retrospective chart review of sixteen patients with chronic knee pain who paid for intra-articular injections

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Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness

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