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Rather than requiring complete environmental control, the cellular approach focuses on strengthening the foundation that makes everything else work better

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This protein is produced by several cells in the body, including epithelial cells of the small intestine

Pharmacol Rev 54:101127 Talebi S, Bolhassani A, Azad TM, Arashkia A, Modaresi MH (2017) Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines

Model performance: Sensitivity = 0.865, Positive Predictive Value = 0.828, AUC = 0.868