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When HK-2 cells were treated with MLN4924, the UBE2m overexpression-induced increase in neddylation and expression of NEDD4 was rescued, as was the decrease in PPAR expression induced by NEDD4 elevation (Fig

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Therefore, targeting the intestinal barrier with dietary bioactive L-SOD could be a promising glucose-lowering approach to reset HMRD-induced new onset diabetes in PASC patients