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The nine tissue systems now documented in the preclinical literature were not predicted by computational models or receptor-binding assays at the outset they were identified sequentially as researchers in different laboratories independently tested the compound against different experimental injury models and consistently found meaningful effects

J Clin Invest 1963;42:1816 1834

Mobasher et al., 2022

Patterson et al

LC and EP were funded by Cancer Research UK Discovery Programme Grant (A28278)

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