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doi: 10.1016/j.ctim.2022.102819 150 SuMZhaoWXuS

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doi: 10.1136/bcr-2015-213189

Although the nanoparticle drug delivery system was not initially designed for LDL-receptor-mediated brain targeting, it was later found that apolipoprotein E would be absorbed on the polysorbate 80 coated nanoparticles upon incubation of the nanoparticles with human plasma resulting in LDL-receptor mediated BBB crossing