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Metformin attenuates Monosodium-Iodoacetate-Induced osteoarthritis via regulation of pain mediators and the Autophagy-Lysosomal pathway

The hepatocytes were arranged in the form of plates radiating from the central vein

47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

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10.1038/s41593-019-0418-z 121 LloydA

Doi:10.1038/nature03000 Malinda KM, Sidhu GS, Mani H, et al