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For instance, TCM herbs such as Coptis chinensis, Curcuma longa, Gynostemma pentaphyllum, and SMS, as well as Tibetan medicinal materials like Potentilla anserina, Rhodiola crenulata and its derivatives, all exert neuroprotective effects and maintain the integrity of the BBB by regulating signaling pathways such as NF-B, inhibiting the release of inflammatory cytokines and alleviating oxidative damage

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In each case, 5FU treatment reduced the IC 50 of ETC inhibitors, demonstrating that 5FU treatment enhances dependency on ETC function

May 1 2017;23(3):322-337

(C) Random Forest (RF) analysis using metabolite data derived from sera collected at baseline, or at 12 and 24 weeks ULT titration to target