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Moreover, when only a small number of route constraints are active at dual optimality, the optimal dual face may retain considerable freedom

The trial had a 26-week treatment period, including a 6-week dose-escalation period, and a 6-week follow-up period without treatment

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By maintaining gut barrier integrity and reducing the translocation of LPS, LPS can trigger significant inflammatory responses primarily through the activation of the TLR4 signaling pathway, which leads to the production of pro-inflammatory cytokines (108)

Cakir E, Ozcan O, Yaman H, Akgul EO, Bilgi C, Erbil MK

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