As TP53 mutations are strong drivers of negative outcomes in multiple hematologic malignancies, as exemplified by relapsed pediatric acute lymphoblastic leukemia, APR-246 may likely have more broad clinical implications including synergy with traditional cytotoxic agents, as has been recently described.20 Together, shedding light on the synergistic mechanisms underlying APR-246 and azacitidine therapy as presented in this study are critical to continue to advance this novel therapeutic option for patients with the poorest outcomes to traditional treatments
Also, as with any supplement, you should speak with your doctor to determine whether glutathione is right for you
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10.1053/j.gastro.2020.04.077 20 ChuS.NiuZ.GuoQ.BiH.LiX.LiF.et al (2020)
A loading phase of 1mg three times weekly for two weeks, then maintenance of 1mg every two to three months, adjusted for the cause and any neurological involvement
Risks: Bleeding, infections, or serious issues with anaesthesia or blood clots