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Thus, GSH plays the role of a mediator in crucial cellular processes, such as cell cycle progression and programmed cell death ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by -glutamylcysteine synthetase (-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) (Noctor et al., 2002, 2012

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Targeting glutathione and cystathionine beta-synthase in ovarian cancer treatment by selenium-chrysin polyurea dendrimer nanoformulation

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2,8,11 The onset and duration of CIPN signs and symptoms have a variable time line, beginning weeks to months after treatment initiation and peaking upon, or after, treatment discontinuation

doi: 10.1007/s13402-023-00831-8