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24 The peptides ability to modulate nitric oxide and inflammatory cytokines may underlie these effects
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
Call to Action Lyophilized (freeze-dried) peptides should be stored at -20C or colder in a light- and moisture-protected environment
MLCK-mediated intestinal permeability promotes immune activation and visceral hypersensitivity in PI-IBS mice
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