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458 CTLA-4 inhibitor ipilimumab has been approved by the FDA for the treatment of advanced metastatic melanoma, while it also exhibited modest antitumor activity observed in TNBC

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Relevance to autoimmune conditions: Balances Th1/Th2 immune response (psoriasis involves Th17/Th1 dysregulation) Enhances regulatory T-cell function Reduces autoimmune overactivation without immunosuppression Caution: If you're on biologics (Humira, Enbrel, etc.) or immunosuppressants, Thymosin Alpha-1 could theoretically interfere

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The mast cells mainly reside in connective tissue, in which the extracellular matrix is made of proteins that hold the tissue together

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