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While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)

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Front Mol Neurosci 16:1113081 Ma D et al (2021) Inhibition of ferroptosis attenuates acute kidney injury in rats with severe acute pancreatitis

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Furthermore, mitochondrial dysfunction can trigger apoptosis and necrosis by releasing proteins like Cytc into the cytoplasm