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In recessive diseases, the pathology is determined by variants (in homozygosity or heterozygosity) in both alleles

Jian Li, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Following treatment, the medium was removed, cells were washed 2 times with warm PBS, and fixed with 4% formaldehyde for 20 min

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