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Neurotoxicology 27(6): 931-939

A swallowed molecule rarely reaches circulation intact: its oral bioavailability collapses to a few percent, when it is not zero

PMCID: PMC6359887

Glutathione is synthesized in the cytosol of each cell by the action of two enzymes in an elegantly regulated system that allows it to be maintained at different homeostatic levels in different tissue types, with the liver, given its detoxification role, having the highest amounts

The lack of highly effective treatments for many peripheral neuropathies creates clinical need for novel therapeutics

Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia