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How to Take Vitamin B12 Supplements Safely Vitamin B12 supplements are generally considered very safe, even at doses far exceeding the recommended daily intake, because it is water-soluble and excess amounts are typically excreted in urine

arguments against the use of oral cobalamin Oral treatment may be considered in certain situationsfor example, in mild or subclinical deficiency with no clinical features and when absorption and compliance are definitely not a problem

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